SAFETY, TOLERABILITY, AND DOSE-LIMITING TOXICITY OF LACOSAMIDE IN PATIENTS WITH PAINFUL CHRONIC PANCREATITIS: PROTOCOL FOR A PHASE 1 CLINICAL TRIAL TO DETERMINE SAFETY AND IDENTIFY SIDE EFFECTS

BackgroundChronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for Western Style Bridles and Breastplate pain control.Although several management options are available, outcomes are often disappointing, and opioids remain a mainstay of therapy.Opioid-induced hyperalgesia

Abstract Background Duplication of urethra is a very rare congenital disorder.Several types of this anomaly have been reported around the world, and are also discussed in this report.However, the mechanism of this anomaly is still unclear.Case A 45-year-old Persian man with a complaint of recurrent urinary tract infection was referred to our clinic

The genetic merit of individuals can be estimated using models with dense markers and pedigree information.Early genomic models accounted only for additive effects.However, the prediction of non-additive effects is important for different forest breeding systems where the whole genotypic value can be captured through clonal propagation.In this stud

PurposeNephrolithiasis is thought to be a risk factor for osteoporosis, but data assessing if osteoporosis predisposes to the risk of nephrolithiasis are lacking.The present study aims to investigate whether patients with nephrolithiasis have a prominently higher prevalence Copas Menstruales of osteoporosis than the controls and vice versa via a cu

The Distributed Generator of a Photovoltaic System (DGPVS) is an essential factor for future power plant generation, and it can be created by connecting multiple small power plant generators in a microgrid system.This paper focuses on the overcurrent protection of a three-phase grid-connected inverter (3P-GCI) under voltage sag conditions in sustai